Gene/Protein Disease Symptom Drug Enzyme Compound
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Query: UMLS:C0221168 (podagra)
 60 document(s) hit in 31,850,051 MEDLINE articles (0.00 seconds)

Thirty patients with gouty arthritis were studied over 3 years. The diagnosis was established with the help of polarised light microscopy. All the patients were males, with a median age of 45 years. They belonged to the middle or upper socio-economic class and were obese (mean body mass index 29.7). Chronic alcoholism, diabetes mellitus and hypertension were present in one patient each. No patient had symptomatic coronary artery disease. Although 6 patients had a history of renal colic, only one had gouty nephropathy with chronic renal failure. Six patients had a positive family history of gout. The disease involved mostly the joints of the lower extremity and podagra was observed in 70% of patients. Eight patients had tophi at various sites. There were 17 'over producers' and 13 'under excretors' of uric acid. The treatment consisted of patient education, symptomatic control with non steroidal anti-inflammatory drugs and/or colchicine and antihyperuricaemic therapy. The overproducers were treated with allopurinol while the under excretors were treated with [corrected] sulfinpyrazone. In general, there was a good response to therapy as indicated by lowering of serum uric acid and the number of painful episodes per year. The overall profile of the disease appears similar to that seen in the West.
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PMID:Clinical profile, therapeutic approach and outcome of gouty arthritis in northern India. 238 54

The efficacy of isolated and combined treatment of renal lesions sallopurionol (milurit), potassium orotate, azathioprin (6-mercaptopurin) was studied in 207 inpatients with primary podagra. Citrate mixtures, urinary antiseptic and hypotensive agents were used when indicated. Follow-up results from 1 to 12 years are analyzed. Prolonged systematic complex treatment of podagric nephropathy is medically and economically effective.
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PMID:[The treatment results in patients with gouty nephropathy]. 239 29

Six women with acute calcific periarthritis of the first metatarsophalangeal joint (hydroxyapatite pseudopodagra) are described, and 10 previously reported cases (8 female patients and 2 male patients) are reviewed. The onset was characterized by acute pain, swelling, erythema, tenderness, and limitation of movement of the first metatarsophalangeal joint, symptoms indistinguishable from those of gouty podagra, which is associated with transient amorphous calcific deposits in the vicinity of the joint. Based on these results it appears that hydroxyapatite pseudopodagra is a disorder that predominantly affects premenopausal women.
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PMID:Hydroxyapatite pseudopodagra. A syndrome of young women. 236 Sep 55

62 obese patients (44 women, and 18 men), mean age 43 years, were treated for one month in the rehabilitation center in Loznitsa by a hypocaloric diet and e physically active regimen. The average reduction of body mass was 11,248 +/- 3,392 kg. The treatment led to a marked ketosis--increase of pyruvate, acetacetate and beta-hydroxybutyrate, the increase of the most active metabolic component--beta-hydroxybutyrate being the greatest. The increased ratio beta-hydroxybutyrate/acetacetate could be considered favourable in relation to the energetic dysbalance since beta-hydroxybutyrate metabolizes faster than acetacetate. In patients with disturbed glucose tolerance, as well-as in patients with liver and renal diseases, gallstone disease, podagra and disturbed calcium-phosphorus metabolism the body mass reducing regimen should be carried out strictly individually and carefully in order to avoid the unfavourable effect of severe metabolic disturbances which could arise because of pronounced ketoacidosis.
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PMID:[Metabolic ketoacidosis in obese subjects resulting from dietetic and exercise regimens to reduce excess body weight]. 274 41

Of the 228 patients with crystal-induced arthritis (194 cases of gouty arthritis, 34 cases of pseudogout) seen between 1976 and 1985 at the Medical Service of Chulalongkorn hospital in Bangkok, 46 of them or 20.2 per cent of the total were female. The females with crystal-induced arthritis included 22 cases of gouty arthritis and 24 cases of pseudogout. Pseudogout was seen more commonly than gouty arthritis during the 10-year period. Both types exhibited a similar pattern with regard to late onset of disease at age 60 or more (75% of the cases with pseudogout and 54% of those with gouty arthritis), monoarticular arthritis as the initial manifestation (83.3% of those with pseudogout and 59.1% of those with gouty arthritis), intermittent pattern (54.2% of those with pseudogout and 86.4% of those with gouty arthritis) and the presence of precipitating factors (37.5% of those with pseudogout and 45.5% of those with gouty arthritis). However, different patterns were observed with regard to the joint of involvement: the knee joint was the most commonly involved joint in pseudogout (75%) but the ankle joint was seen in cases of gouty arthritis (86.4%). Podagra was not observed in cases of pseudogout, although in 22.7% of the patients with gouty arthritis, it was the initial manifestation of the disease. In subsequent attacks of arthritis, monoarticular arthritis (61.5%) and knee joint involvement (75%) were the main features of pseudogout. Oligoarticular arthritis (63.2%) and ankle joint involvement (86.4%) were the main feature of gouty arthritis.(ABSTRACT TRUNCATED AT 250 WORDS)
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PMID:Clinical pattern of females with crystal-induced arthritis: gout and pseudogout. 278 18

Twenty-two (11.3%) of 194 gouty patients were female. The age at onset was earlier than the 40th year in only 4.5 per cent of the females compared with 19.7 per cent of the males. However, in 54.5 per cent of the female patients compared with 38.4 per cent of the males, the age at onset was 60 years or more. Although the initial manifestation of the disease was acute monoarticular arthritis, with involvement of the ankle joint being more commonly observed in the female patients (63.3%) than in the males (37.2%), and by contrast, with involvement of the first metatarsophalangeal joint (podagra) being more frequently noted in the males (45.9%) than in the females (22.7%). In subsequent attacks, oligoarticular arthritis and arthritis of the ankle joints were predominant features of the disease in both sexes. However, podagra was less frequently evident in the female patients (31.8%) than in the males (68.5%) as were tophi (18.2 and 31.4%, respectively); specifically, in those females with tophi, the tophaceous manifestation developed in all of them within four years of the onset of the disease compared with only 27.8 per cent of the males with tophi. Moreover, although provocative factors and associated diseases were present in both sexes, haematologic malignancy was more common in the females (22.7%) than in the males (2.9%). In conclusion, although the clinical features of gout in females are similar to those in males, gout in females is characterized by later onset of the disease, earlier development of tophi and arthritis of the ankle joint.
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PMID:A clinical comparison of females and males with gouty arthritis. 280 56

A 72-year-old female with a recent episode of podagra, without peripheral tophi, presented with nocturnal back pain and a destructive lesion of the right lamina of L4. A tophus was excised at laminectomy. Evidence of an axial skeletal tophus causing an irritative radiculopathy via mass effect is presented.
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PMID:Tophaceous gout of the axial skeleton. 297 40

The presence of crystal proven podagra coincident with a 52% decrease in plasma urate after a 3-day course of total parenteral nutrition (TPN) prompted a study of urate excretion in 9 patients with Crohn's disease. By Day 9 in those receiving TPN, plasma urate decreased 58% (p less than 0.001), while fractional urate excretion increased 94% (p less than 0.005). Twenty-four hour urate excretion and serum creatinine were not significantly altered. These findings persisted for the duration of TPN. In 2 patients with ileocolitis, the addition or deletion of either lipid emulsion or multivitamin infusions during TPN had no effect on urate values. Rather, the amino acid load or a specific constituent appears to be the causal factor. These data suggest that hypouricemia due to extensive net urate excretion is common during TPN therapy. Finally, patients with established gout may be at risk for acute gouty attacks during TPN therapy.
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PMID:Altered fractional excretion of uric acid during total parenteral nutrition. 312 76

1 The natural history of acute gouty arthritis was studied in 11 volunteers with podagra. 2 Two patients withdrew from the study on day 4 because of severe persistent pain. Of the remaining patients all showed some improvement in pain by day 5 and in swelling by day 7. Tenderness improved in seven patients by day 7 but two continued to experience the same amount of discomfort as at trial entry. In spite of these improvements only three patients noted resolution of their pain during the study period. 3 These data indicate that while the majority of patients show spontaneous improvement, resolution is unlikely over a period of 7 days without the use of effective non-steroidal anti-inflammatory medication. 4 Documentation of the natural history of the acute gouty attack may assist clinical investigators in interpreting the results of uncontrolled evaluations of non-steroidal anti-inflammatory drugs.
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PMID:Observations on spontaneous improvement in patients with podagra: implications for therapeutic trials of non-steroidal anti-inflammatory drugs. 330 84

Recently, calcium oxalate crystals have been identified in the synovial fluid of patients with arthritis and end-stage renal failure. We describe 4 patients who, during the course of long-term hemodialysis, developed calcium oxalate crystal deposits in the synovium and skin. Clinical manifestations included podagra, tenosynovitis, olecranon bursitis, and acute and chronic synovitis of the large joints that were associated with chondrocalcinosis or subchondral bone erosions. Diffuse involvement of the hand, with chondrocalcinosis of the finger joints, miliary calcified deposits in the skin, and artery calcifications, was observed in 3 patients. The fourth patient had erosive arthropathy. Oxalosis secondary to end-stage renal failure in patients treated with long-term hemodialysis can present with articular manifestations that resemble those of gout, pseudogout, and apatite deposition disease. Other characteristic features of the synovitis associated with oxalosis secondary to end-stage renal disease were: predominant involvement of the hand, mild inflammatory changes in the synovial fluid and synovium, and poor response to administration of nonsteroidal antiinflammatory agents.
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PMID:Arthropathy and cutaneous calcinosis in hemodialysis oxalosis. 377 44


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